Telmisartan Prevents Myocardial Fibrosis : Telmisartan Decreases TGF-β1 and Collagen Fraction Volume Myocardial Tissue in Wistar Rats Induced High Salt Intake
نویسندگان
چکیده
Congestive heart failure (CHF) is mainly resulted from fibrosis heart. Accumulation collagen in heart fibrosis occurs as result from activity of myofibroblast [1-4]. Myofibroblast is throught to be driven by extracellular stimuli, transformation growth factor β1 (TGF-β1) is one of major player. Interestingly, if the surrounding pathogenic factors are removed, myofibroblast has potential possibility to be reversed [5-11]. Beyond delaying the inevitable onset of CHF cessation and regression of myofibroblast are ideal schemes of clinical treatment. Realizing the process of myofibroblast is essential in establishing therapeutic strategies for progressive CHF, the pathway to counteract and reverse myofibroblast seems to be focused.
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